Parasite virulence factors during falciparum malaria: rosetting, cytoadherence, and modulation of cytoadherence by cytokines
نویسندگان
چکیده
منابع مشابه
Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes.
Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have studied two host factors, the spleen and antibody, that influence sequestration of P. falciparum in the squirrel monkey. Sequestration of trophozoite/s...
متن کاملAlteration in cytoadherence and rosetting of Plasmodium falciparum-infected thalassemic red blood cells.
Hemoglobinopathies have a protective role in malaria that appears to be related to alterations in red blood cell (RBC) properties. Thalassemic RBCs infected with Plasmodium falciparum showed greatly reduced cytoadherence and rosetting properties as well as impaired growth and multiplication. A significant decrease in the levels of falciparum antigens associated with the membrane of infected bet...
متن کامل: Malaria Red Cell Cytoadherence Response
132-m (2) and tryptophan in Rab 12 kD (1). The possibility that the assignment of tryptophan results from a typographical error in figure 2 of Brinckerhoff et al. (1) is suggested by the misquoted assignment in that figure of tryptophan, instead of tyrosine, at the same position of human P2-m, the only sequence to which Rab 12 kD is compared. PETER PARHAM Department of Cell Biology, Shernan Fai...
متن کاملHost response to cytoadherence in Plasmodium falciparum.
Cytoadherence of PRBCs (Plasmodium falciparum-infected red blood cells) to host endothelium has been associated with pathology in severe malaria, but, despite extensive information on the primary processes involved in the adhesive interactions, the mechanisms underlying the disease are poorly understood. Endothelial cells have the ability to mobilize immune and pro-adhesive responses when expos...
متن کاملPathogenesis of cerebral malaria—inflammation and cytoadherence
Despite decades of research on cerebral malaria (CM) there is still a paucity of knowledge about what actual causes CM and why certain people develop it. Although sequestration of P. falciparum infected red blood cells has been linked to pathology, it is still not clear if this is directly or solely responsible for this clinical syndrome. Recent data have suggested that a combination of parasit...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1993
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.61.12.5198-5204.1993